Glutamine and glutamic acids are closely related amino acids. The human body is able to create L-glutamine itself from glutamic acids through ammonia-glutamic ligase. Given the many metabolic activities in which glutamine is involved, it is not surprising that glutamine is the amino acid with the highest concentration in blood plasma, muscle tissue, and cerebrospinal fluid (from the brain and spinal cord). Glutamine accounts for 60% of all amino acids in the body, making it the most abundant amino acid in the body. The need for glutamine increases with physical and mental stress, as well as in cases of stress. However, it is often found that the endogenous production of this crucial amino acid decreases significantly with age. It is therefore advisable to compensate for this deficiency through exogenous supplementation.